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KMID : 0811720130170040339
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Korean Journal of Physiology & Pharmacology
2013 Volume.17 No. 4 p.339 ~ p.345
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Effect of Lutein on L-NAME-Induced Hypertensive Rats
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Sung Ji-Hoon
Jo Young-Soo
Kim Su-Jin
Ryu Jeong-Soo
Kim Myung-Chul
Ko Hyun-Ju
Sim Sang-Soo
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Abstract
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We investigated the antihypertensive effect of lutein on NG-nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertensive rats. Daily oral administration of L-NAME (40 mg/kg)-induced a rapid progressive increase in mean arterial pressure (MAP). L-NAME significantly increased MAP from the first week compared to that in the control and reached 193.3±9.6 mmHg at the end of treatment. MAP in the lutein groups was dose-dependently lower than that in the L-NAME group. Similar results were observed for systolic and diastolic blood pressure of L-NAME-induced hypertensive rats. The control group showed little change in heart rate for 3 weeks, whereas L-NAME significantly reduced heart rate from 434±26 to 376±33 beats/min. Lutein (2 mg/kg) significantly prevented the reduced heart rate induced by L-NAME. L-NAME caused hypertrophy of heart and kidney, and increased plasma lipid peroxidation four-fold but significantly reduced plasma nitrite and glutathione concentrations, which were significantly prevented by lutein in a dose-dependent manner. These findings suggest that lutein affords significant antihypertensive and antioxidant effects against L- NAME-induced hypertension in rats.
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KEYWORD
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Antioxidant, Hypertension, Lipid peroxidation, L-NAME, Lutein
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